Article
Genetic Polymorphism of GABRR2 Modulates Individuals' General Cognitive Ability in Healthy Chinese Han People.
Cellular and molecular neurobiology - 1 Jan 2017
Ma Zhe, Niu Binbin, Shi Zhangyan, Li Junlin, Wang Jian, Zhang Fuchang, Gao Xiaocai, Zhang Kejin
Abstract excerpt
Previous studies have indicated that the cognitive impairment or deficit is associated with GABAergic signaling in central nervous system. Inspired by the finding that receptor GABRR2 modulates concentration of GABA and phasic inhibitory GABAergic transmission in brain. This study investigated to what extent a genetic variant (c.1423C>T, rs282129) of GABRR2 gene modulates individuals' general cognitive ability in...
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