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Article

β-Arrestin-2 Counters CXCR7-Mediated EGFR Transactivation and Proliferation.

Molecular cancer research : MCR - 1 May 2016

Kallifatidis Georgios, Munoz Daniel, Singh Rajendra Kumar, Salazar Nicole, Hoy James J, Lokeshwar Bal L

Abstract excerpt

UNLABELLED: The atypical 7-transmembrane chemokine receptor, CXCR7, transactivates the EGFR leading to increased tumor growth in several tumor types. However, the molecular mechanism of CXCR7 ligand-independent EGFR transactivation is unknown. We used cDNA knock-in, RNAi and analysis of mitogenic signaling components in both normal prostate epithelial cells and prostate cancer cells to decipher the...

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Source

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Identifiers

PMID: 26921391
DOI: 10.1158/1541-7786.MCR-15-0498
PMCID: PMC4867265

Genes

EGFR
AREG
ARRB2
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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