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Article

Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation.

The Journal of biological chemistry - 20 Dec 2002

Sun Yue, Cheng Zhijie, Ma Lan, Pei Gang

Abstract excerpt

Chemotaxis mediated by chemokine receptors such as CXCR4 plays a key role in lymphocyte homing and hematopoiesis as well as in breast cancer metastasis. We have demonstrated previously that beta-arrestin2 functions to attenuate CXCR4-mediated G protein activation and to enhance CXCR4 internalization. Here we show further that the expression of beta-arrestin2 in both HeLa and human embryonic kidney 293 cells...

Read the complete abstract on PubMed

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Share to Arrestins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to p38 Mitogen-Activated Protein Kinases

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Source

Identifiers

PMID: 12370187
DOI: 10.1074/jbc.M207294200

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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