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Article

Positive Feedback Activation of Estrogen Receptors by the CXCL12-CXCR4 Pathway

7 Jul 2009

Abstract excerpt

Induction of estrogen-regulated gene transcription by estrogen receptors ERalpha and ERbeta plays an important role in breast cancer development and growth. High expression of the chemokine receptor CXCR4 and its ligand CXCL12/stromal cell-derived factor 1 (SDF-1) has also been correlated with aggressive breast tumor phenotypes. Here, we describe a positive regulatory loop between the CXCR4/SDF-1 signaling...

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Share to Chemokine receptors and signaling
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PMID: 19584281
DOI: 10.1158/0008-5472.can-08-4924

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