Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response.

doi:10.1186/s13073-016-0276-1

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Article

Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response.

Genome medicine - 25 Feb 2016

Godoy-Lozano Elizabeth Ernestina, Téllez-Sosa Juan, Sánchez-González Gilberto, Sámano-Sánchez Hugo, Aguilar-Salgado Andrés, Salinas-Rodríguez Aarón, Cortina-Ceballos Bernardo, Vivanco-Cid Héctor, Hernández-Flores Karina, Pfaff Jennifer M, Kahle Kristen M, Doranz Benjamin J, Gómez-Barreto Rosa Elena, Valdovinos-Torres Humberto, López-Martínez Irma, Rodriguez Mario H, Martínez-Barnetche Jesús

Abstract excerpt

BACKGROUND: The study of human B cell response to dengue virus (DENV) infection is critical to understand serotype-specific protection and the cross-reactive sub-neutralizing response. Whereas the first is beneficial and thus represents the ultimate goal of vaccination, the latter has been implicated in the development of severe disease, which occurs in a small, albeit significant, fraction of secondary DENV...

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Identifiers

PMID: 26917418
DOI: 10.1186/s13073-016-0276-1
PMCID: PMC4766701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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