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Article

F99 is critical for dimerization and activation of South African HIV-1 subtype C protease.

The protein journal - 1 Oct 2013

Naicker Previn, Seele Palesa, Dirr Heini W, Sayed Yasien

Abstract excerpt

HIV-1 protease (PR) is an obligate homodimer which plays a pivotal role in the maturation and hence propagation of HIV. Although successful developments on PR active site inhibitors have been achieved, the major limiting factor has been the emergence of HIV drug-resistant strains. Disruption of the dimer interface serves as an alternative mechanism to inactivate the enzyme. The terminal residue, F99, was mutated...

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Identifiers

PMID: 24132393
DOI: 10.1007/s10930-013-9517-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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