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Article

Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance

12 Nov 2012

Abstract excerpt

The HIV protease plays a major role in the life cycle of the virus and has long been a target in antiviral therapy. Resistance of HIV protease to protease inhibitors (PIs) is problematic for the effective treatment of HIV infection. The South African HIV-1 subtype C protease (C-SA PR), which contains eight polymorphisms relative to the consensus HIV-1 subtype B protease, was expressed in Escherichia coli,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23140382
DOI: 10.1080/07391102.2012.736774

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