Article
A novel DNA biosensor integrated with Polypyrrole/streptavidin and Au-PAMAM-CP bionanocomposite probes to detect the rs4839469 locus of the vangl1 gene for dysontogenesis prediction.
Biosensors & bioelectronics - 15 Jun 2016
Li Qingying, Yu Chao, Gao Rufei, Xia Chunyong, Yuan Guolin, Li Yuliang, Zhao Yilin, Chen Qiutong, He Junlin
Abstract excerpt
The single nucleotide polymorphism (SNP) of the vangl1 gene is highly correlated with Neural Tube Defects (NTDs), a group of severe congenital malformations. It is hindered by the lack of a quantitative detection method. We first propose the use of a DNA biosensor to detect the missense single nucleotide polymorphism (rs4839469 c.346G>A p.Ala116Thr) of the vangl1 gene in this work. Polypyrrole (PPy) and...
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