Article
Applicability of Hepatitis C Virus RNA Viral Load Thresholds for 8-Week Treatments in Patients With Chronic Hepatitis C Virus Genotype 1 Infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 May 2016
Vermehren Johannes, Maasoumy Benjamin, Maan Raoel, Cloherty Gavin, Berkowski Caterina, Feld Jordan J, Cornberg Markus, Pawlotsky Jean-Michel, Zeuzem Stefan, Manns Michael P, Sarrazin Christoph, Wedemeyer Heiner
Abstract excerpt
BACKGROUND: Interferon-free treatment of chronic hepatitis C virus (HCV) genotype 1 infection may be shortened to 8 weeks in treatment-naive, noncirrhotic patients with baseline HCV RNA levels of <4 or <6 million (M) IU/mL based on post-hoc analyses of phase 3 trial data. The applicability of these viral load thresholds in clinical practice is unknown. METHODS: Pretreatment and on-treatment serum samples (n =...
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