Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jul 2011

Lee Crystal J J, Gonçalves Luisa L, Wells Peter G

Abstract excerpt

Thalidomide (TD) displays remarkable species specificity, causing birth defects (teratogenesis) in humans and rabbits, but not rats or mice; yet, few determinants of species susceptibility have been identified. Also, certain mouse strains are susceptible to the embryopathic effects of some teratogens in embryo culture despite their resistance in vivo. Herein we show that CD-1 mouse embryos in culture are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abnormalities, Drug-Induced
Share to DNA Glycosylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo Culture Techniques

Share to Fetal Diseases

Share to Hydrolysis

Share to Mice, Inbred Strains

Share to Teratogens

Share to Thalidomide

Source

Identifiers

PMID: 21505090
DOI: 10.1093/toxsci/kfr084

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture.PMID 21505090Read ↗

Embryopathic effects of thalidomide and its hydrolysis products in rabbit embryo culture: evidence for a prostaglandin H synthase (PHS)‐dependent, reactive oxygen species (ROS)‐mediated mechanismSemantic proximity Read ↗

Species‐specificity of ethylene glycol‐induced developmental toxicity: toxicokinetic and whole embryo culture studies in the rabbitSemantic proximity Read ↗

A review of the contribution of whole embryo culture to the determination of hazard and risk in teratogenicity testingSemantic proximity Read ↗

The Molecular Mechanisms of Thalidomide Teratogenicity and Implications for Modern Medicine.Semantic proximity Read ↗

Mechanisms regulating toxicant disposition to the embryo during early pregnancy: An interspecies comparisonSemantic proximity Read ↗

Comparison of rat and rabbit embryo–fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effectsSemantic proximity Read ↗

Apparent lability of neural tube closure in laboratory animals and humans.Semantic proximity Read ↗

Thalidomide-induced limb abnormalities in a humanized CYP3A mouse modelSemantic proximity Read ↗

Altered methanol embryopathies in embryo culture with mutant catalase-deficient mice and transgenic mice expressing human catalase.Semantic proximity Read ↗

An embryoprotective role for glucose-6-phosphate dehydrogenase in developmental oxidative stress and chemical teratogenesis.Semantic proximity Read ↗

Polymorphic susceptibility to the molecular causes of neural tube defects during diabetic embryopathy.Semantic proximity Read ↗

Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.