Article
Expression of human cytochromes P450 in chimeric mice with humanized liver.
Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2004
Katoh Miki, Matsui Tomohito, Nakajima Miki, Tateno Chise, Kataoka Miho, Soeno Yoshinori, Horie Toru, Iwasaki Kazuhide, Yoshizato Katsutoshi, Yokoi Tsuyoshi
Abstract excerpt
Recently, a chimeric mouse line in which the liver could be replaced by more than 80% with human hepatocytes was established in Japan. Because the chimeric mouse produces human albumin (hAlb), replacement by human hepatocytes could be estimated by the hAlb concentration in the blood of chimeric mice. In this study, we investigated human major cytochrome P450 (P450) in the livers of chimeric mice by mRNA, protein,...
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