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Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides

22 Feb 2016

Abstract excerpt

Apolipoprotein E receptor 2 (ApoER2) is an apolipoprotein E receptor involved in long‐term potentiation, learning, and memory. Given its role in cognition and its association with the Alzheimer's disease (AD) risk gene, apoE, ApoER2 has been proposed to be involved in AD, though a role for the receptor in the disease is not clear. ApoER2 signaling requires amino acids encoded by alternatively spliced exon 19....

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PMID: 26902204
DOI: 10.15252/emmm.201505846

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