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Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death

22 Feb 2016

Abstract excerpt

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus showing a recent resurgence and rapid spread worldwide. While vaccines are under development, there are currently no therapies to treat this disease, except for over-the-counter (OTC) analgesics, which alleviate the devastating arthritic and arthralgic symptoms. To identify novel inhibitors of the virus, analogues of the natural product bryostatin 1, a...

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PMID: 26900625
DOI: 10.1021/acs.jnatprod.5b01016

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