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Article

Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments.

Antimicrobial agents and chemotherapy - 1 Mar 2017

Varghese Finny S, Rausalu Kai, Hakanen Marika, Saul Sirle, Kümmerer Beate M, Susi Petri, Merits Andres, Ahola Tero

Abstract excerpt

As new pathogenic viruses continue to emerge, it is paramount to have intervention strategies that target a common denominator in these pathogens. The fusion of viral and cellular membranes during viral entry is one such process that is used by many pathogenic viruses, including chikungunya virus, West Nile virus, and influenza virus. Obatoclax, a small-molecule antagonist of the Bcl-2 family of proteins, was...

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Identifiers

PMID: 27993855
DOI: 10.1128/AAC.02227-16
PMCID: PMC5328557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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