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Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection

30 Dec 2024

Abstract excerpt

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus causing fever, myalgia, and debilitating joint swelling and pain, which in many patients becomes chronic. The frequent epidemics of CHIKV across the world pose a significant public health burden necessitating the development of effective antiviral therapeutics. A cellular imaging-based high-content screening of natural compounds identified withaferin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39775571
DOI: 10.1371/journal.ppat.1012816

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