Collagen I and the fibroblast: High protein expression requires a new paradigm of post-transcriptional, feedback regulation

Abstract excerpt

BACKGROUND: Scaling protein production seems like a simple perturbation of transcriptional control. However, when embryonic tendon fibroblasts have to produce >50% procollagen and secrete it from the cell 4 times faster than the average protein, this taxes the cellular machinery and requires a fresh look at how the pathway is controlled. Ascorbate, a reducing agent, can stimulate procollagen production 6-fold....

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