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Article

Ascorbic acid promotes a TGFβ1-induced myofibroblast phenotype switch.

Physiological reports - 1 Sept 2017

Piersma Bram, Wouters Olaf Y, de Rond Saskia, Boersema Miriam, Gjaltema Rutger A F, Bank Ruud A

Abstract excerpt

l-Ascorbic acid (AA), generally known as vitamin C, is a crucial cofactor for a variety of enzymes, including prolyl-3-hydroxylase (P3H), prolyl-4-hydroxylase (P4H), and lysyl hydroxylase (LH)-mediated collagen maturation. Here, we investigated whether AA has additional functions in the regulation of the myofibroblast phenotype, besides its function in collagen biosynthesis. We found that AA positively influences...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28904079
DOI: 10.14814/phy2.13324
PMCID: PMC5599854

Genes

ACTA2
CCN2
DDR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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