Article
Hepatitis E Virus (HEV) Genotype 3 Infection of Human Liver Chimeric Mice as a Model for Chronic HEV Infection.
Journal of virology - 1 May 2016
van de Garde Martijn D B, Pas Suzan D, van der Net Guido, de Man Robert A, Osterhaus Albert D M E, Haagmans Bart L, Boonstra Andre, Vanwolleghem Thomas
Abstract excerpt
UNLABELLED: Genotype 3 (gt3) hepatitis E virus (HEV) infections are emerging in Western countries. Immunosuppressed patients are at risk of chronic HEV infection and progressive liver damage, but no adequate model system currently mimics this disease course. Here we explore the possibilities of in vivo HEV studies in a human liver chimeric mouse model (uPA(+/+)Nod-SCID-IL2Rγ(-/-)) next to the A549 cell culture...
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