Article
An Immunocompetent Mongolian Gerbil Model for Hepatitis E Virus Genotype 1 Infection.
Gastroenterology - 1 Sept 2024
Liu Tianxu, He Qiyu, Yang Xinyue, Li Yuebao, Yuan Disen, Lu Qinghui, Tang Tianyu, Guan Guiwen, Zheng Liwei, Zhang He, Xia Changyou, Yin Xin, Wei Guochao, Chen Xiangmei, Lu Fengmin, Wang Lin
Abstract excerpt
BACKGROUND & AIMS: Hepatitis E virus (HEV), primarily genotype 1 (HEV-1), causes approximately 20.1 million infections, 44,000 deaths, and 3000 stillbirths annually. Current evidence indicates that HEV-1 is only transmitted in humans. Here, we evaluated whether Mongolian gerbils can serve as animal models for HEV-1 infection. METHODS: Mongolian gerbils were used for HEV-1 and hepatitis E virus genotype 3...
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