Article
Renal Function and Hematology in Rats with Congenital Renal Hypoplasia.
Comparative medicine - 1 Feb 2016
Yasuda Hidenori, Amakasu Kohei, Tochigi Yuki, Katayama Kentaro, Suzuki Hiroetsu
Abstract excerpt
Renal hypoplasia due to a congenitally reduced number of nephrons progresses to chronic kidney disease and may cause renal anemia, given that the kidneys are a major source of erythropoietin in adults. Hypoplastic kidney (HPK) rats have only about 20% of the normal number of nephrons and develop CKD. This study assessed the renal function and hematologic changes in HPK rats from 70 to 210 d of age. HPK rats...
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