Article
Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches.
Expert review of gastroenterology & hepatology - 1 Aug 2016
Sahin Ibrahim H, Lowery Maeve A, Stadler Zsofia K, Salo-Mullen Erin, Iacobuzio-Donahue Christine A, Kelsen David P, O'Reilly Eileen M
Abstract excerpt
Pancreatic cancer is one of the most challenging cancers. Whole genome sequencing studies have been conducted to elucidate the underlying fundamentals underscoring disease behavior. Studies have identified a subgroup of pancreatic cancer patients with distinct molecular and clinical features. Genetic fingerprinting of these tumors is consistent with an unstable genome and defective DNA repair pathways, which...
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