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Article

Evidence for Detrimental Cross Interactions between Reactive Oxygen and Nitrogen Species in Leber's Hereditary Optic Neuropathy Cells.

Oxidative medicine and cellular longevity - 1 Jan 2016

Falabella Micol, Forte Elena, Magnifico Maria Chiara, Santini Paolo, Arese Marzia, Giuffrè Alessandro, Radić Kristina, Chessa Luciana, Coarelli Giulia, Buscarinu Maria Chiara, Mechelli Rosella, Salvetti Marco, Sarti Paolo

Abstract excerpt

Here we have collected evidence suggesting that chronic changes in the NO homeostasis and the rise of reactive oxygen species bioavailability can contribute to cell dysfunction in Leber's hereditary optic neuropathy (LHON) patients. We report that peripheral blood mononuclear cells (PBMCs), derived from a female LHON patient with bilateral reduced vision and carrying the pathogenic mutation 11778/ND4, display...

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Identifiers

PMID: 26881022
DOI: 10.1155/2016/3187560
PMCID: PMC4736215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for Detrimental Cross Interactions between Reactive Oxygen and Nitrogen Species in Leber's Hereditary Optic Neuropathy Cells.PMID 26881022Read ↗

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