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Article

alpha-Tocopherol/lipid ratio in blood is decreased in patients with Leber's hereditary optic neuropathy and asymptomatic carriers of the 11778 mtDNA mutation.

Journal of neurology, neurosurgery, and psychiatry - 1 Mar 2001

Klivenyi P, Karg E, Rozsa C, Horvath R, Komoly S, Nemeth I, Turi S, Vecsei L

Abstract excerpt

OBJECTIVES: Leber's hereditary optic neuropathy (LHON) is a maternally inherited disease characterised by acute or subacute bilateral visual loss in young patients. The primary aetiological event is a mutation in the mitochondrial genome (mtDNA) affecting in most cases mtDNA-encoded subunits of the respiratory chain NADH: coenzyme Q oxidoreductase (complex I). The impaired function of complex I leads to a decline...

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Identifiers

PMID: 11181859
DOI: 10.1136/jnnp.70.3.359
PMCID: PMC1737282

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Source receipt: pubmed, retrieved 7 Sept 2026.

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alpha-Tocopherol/lipid ratio in blood is decreased in patients with Leber's hereditary optic neuropathy and asymptomatic carriers of the 11778 mtDNA mutation.PMID 11181859Read ↗

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[Evaluation of serum levels of SOD and MDA in patients with Leber's hereditary optic neuropathy carrying the mitochondrial DNA G11778A mutation].Semantic proximity Read ↗

mtDNA/nDNA ratio in 14484 LHON mitochondrial mutation carriers.Semantic proximity Read ↗

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Functional consequences of the 3460-bp mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.Semantic proximity Read ↗

Functional analysis of lymphoblast and cybrid mitochondria containing the 3460, 11778, or 14484 Leber's hereditary optic neuropathy mitochondrial DNA mutation.Semantic proximity Read ↗

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