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Article

Oestrogens ameliorate mitochondrial dysfunction in Leber’s hereditary optic neuropathy

13 Oct 2010

Abstract excerpt

Leber's hereditary optic neuropathy, the most frequent mitochondrial disease due to mitochondrial DNA point mutations in complex I, is characterized by the selective degeneration of retinal ganglion cells, leading to optic atrophy and loss of central vision prevalently in young males. The current study investigated the reasons for the higher prevalence of Leber's hereditary optic neuropathy in males, exploring...

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PMID: 20943885
DOI: 10.1093/brain/awq276

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