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Article

Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression

17 Oct 2023

Abstract excerpt

BACKGROUND: Although the fusion of the transmembrane serine protease 2 gene (TMPRSS2) with the erythroblast transformation-specific-related gene (ERG), or TMPRSS2-ERG, occurs frequently in prostate cancer, its impact on clinical outcomes remains controversial. Roughly half of TMPRSS2-ERG fusions occur through intrachromosomal deletion of interstitial genes and the remainder via insertional chromosomal...

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PMID: 37847647
DOI: 10.1093/jnci/djad215

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