Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biscarbene gold( i ) complexes: structure–activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability

1 Jan 2017

Abstract excerpt

A series of gold(i) complexes with two N-heterocyclic carbene ligands (biscarbene gold complexes) were prepared and evaluated for their effects against cancer cells and pathogenic bacteria. Proliferation inhibition was observed in cancer cells and in Gram-positive bacteria, whereas Gram-negative bacteria were less sensitive towards the compounds. The protein binding and cellular uptake were quantified and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Click Chemistry and Applications
Share to Metal complexes synthesis and properties

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30108879
DOI: 10.1039/c7md00269f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biscarbene gold( i ) complexes: structure–activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailabilityPMID 30108879Read ↗

Inhibition of Cancer Cell Proliferation and Bacterial Growth by Silver(I) Complexes Bearing a CH3-Substituted Thiadiazole-Based ThioamideSemantic proximity Read ↗

New selective thiolate gold( i ) complexes inhibit the proliferation of different human cancer cells and induce apoptosis in primary cultures of mouse colon tumorsSemantic proximity Read ↗

Gold(III) compounds as anticancer drugsSemantic proximity Read ↗

Synthesis, structures and biomolecular interactions of new silver( i ) 5,5-diethylbarbiturate complexes of monophosphines targeting Gram-positive bacteria and breast cancer cellsSemantic proximity Read ↗

Thioredoxin Reductase Activity Predicts Gold Nanoparticle Radiosensitization EffectSemantic proximity Read ↗

GOLD COMPLEXES - ANTITUMOR PROPERTIES, TARGETS AND MECHANISM OF ACTIONSemantic proximity Read ↗

An in vitro selective inhibitory effect of silver( i ) aminoacidates against bacteria and intestinal cell lines and elucidation of the mechanism of action by means of DNA binding properties, DNA cleavage and cell cycle arrestSemantic proximity Read ↗

Gold(iii) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cellsElectronic supplementary information (ESI) available: Further experimental and crystallographic details. See http://www.rsc.org/suppdata/cc/b3/b303294a/Semantic proximity Read ↗

Organoruthenium metallocycle induced mutation in gld-1 tumor suppression gene in JK1466 strain and appreciable lifespan expansion.Semantic proximity Read ↗

Cytotoxic, pro-apoptotic, pro-oxidant, and non-genotoxic activities of a novel copper(II) complex against human cervical cancerSemantic proximity Read ↗

Dinuclear silver( i ) complexes with a pyridine-based macrocyclic type of ligand as antimicrobial agents against clinically relevant species: the influence of the counteranion on the structure diversification of the complexesSemantic proximity Read ↗

One Stone, Two Birds: A Peptide‐Au(I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.