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Article

Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population.

BMC genomics - 16 Jul 2018

Guo Jintao, Huang Jiankun, Zhou Ying, Zhou Yulin, Yu Liying, Li Huili, Hou Lingyun, Zhu Liuwei, Ge Dandan, Zeng Yuanyuan, Guleng Bayasi, Li Qiyuan

Abstract excerpt

BACKGROUND: Esophageal squamous cell carcinomas (ESCC) is the fourth most lethal cancer in China. Previous studies reveal several highly conserved mutational processes in ESCC. However, it remains unclear what are the true regulators of the mutational processes. RESULTS: We analyzed the somatic mutational signatures in 302 paired whole-exome sequencing data of ESCC in a Chinese population for potential regulators...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30012096
DOI: 10.1186/s12864-018-4906-4
PMCID: PMC6048762

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CDC27

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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