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Mitochondrial DNA variants and susceptibility to anti-tuberculosis drug-induced liver injury in Korean patients.

The pharmacogenomics journal - 29 Oct 2025

Pham Vinh Hoa, Kim Sang-Heon, Jee Young-Koo, Jang Tae-Won, Min Jinsoo, Kim Ho-Sook, Cho Yong-Soon, Shin Jae-Gook

Abstract excerpt

It has been proposed that mitochondrial DNA variations can affect mitochondrial function, increasing the risk of drug-induced liver injury. This study aims to explore the association between mitochondrial DNA (mtDNA) variants and anti-tuberculosis drug-induced liver injury (ATT_DILI) in Korean tuberculosis patients. Whole mitochondrial genomes from 185 patients (61 with ATT_DILI and 124 without liver injury) were...

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PMID: 41162363
DOI: 10.1038/s41397-025-00390-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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