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Article

Filtering genetic variants and placing informative priors based on putative biological function.

BMC genetics - 3 Feb 2016

Friedrichs Stefanie, Malzahn Dörthe, Pugh Elizabeth W, Almeida Marcio, Liu Xiao Qing, Bailey Julia N

Abstract excerpt

High-density genetic marker data, especially sequence data, imply an immense multiple testing burden. This can be ameliorated by filtering genetic variants, exploiting or accounting for correlations between variants, jointly testing variants, and by incorporating informative priors. Priors can be based on biological knowledge or predicted variant function, or even be used to integrate gene expression or other...

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PMID: 26866982
DOI: 10.1186/s12863-015-0313-x
PMCID: PMC4895695

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MAP4
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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