Article
A Non-Synonymous Single Nucleotide Polymorphism in the HJURP Gene Associated with Susceptibility to Hepatocellular Carcinoma among Chinese.
PloS one - 1 Jan 2016
Huang Wenfeng, Zhang Hongxing, Hao Yumin, Xu Xiaobing, Zhai Yun, Wang Shaoxia, Li Yang, Ma Fuchao, Li Yuanfeng, Wang Zhifu, Zhang Yang, Zhang Xiumei, Liang Renxiang, Wei Zhongliang, Cui Ying, Li Yongqiang, Yu Xinsen, Ji Hongzan, He Fuchu, Xie Weimin, Zhou Gangqiao
Abstract excerpt
OBJECTIVE: HJURP (Holliday Junction-Recognizing Protein) plays dual roles in DNA repair and in accurate chromosome segregation during mitosis. We examined whether the single nucleotide polymorphisms (SNPs) of HJURP were associated with the risk of occurrence of hepatocellular carcinoma (HCC) among chronic hepatitis B virus (HBV) carriers from well-known high-risk regions for HCC in China. METHODS: Twenty-four...
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