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Article

Familial Risk in Patients With Carcinoma of Unknown Primary.

JAMA oncology - 1 Mar 2016

Samadder N Jewel, Smith Ken Robert, Hanson Heidi, Pimentel Richard, Wong Jathine, Boucher Kenneth, Akerley Wallace, Gilcrease Glynn, Ulrich Cornelia M, Burt Randall W, Curtin Karen

Abstract excerpt

IMPORTANCE: Carcinoma of unknown primary (CUP) accounts for 3% to 5% of all cancers and is associated with poor prognosis. Familial clustering of different cancer sites with CUP is unknown and may provide information regarding etiology, as well as elevated cancer risks in relatives. OBJECTIVE: To quantify the risk of cancer by site in first- and second-degree relatives and first cousins of individuals with CUP....

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Source

Identifiers

PMID: 26863281
DOI: 10.1001/jamaoncol.2015.4265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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