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Article

Familial risks in cancer of unknown primary: tracking the primary sites.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 2011

Hemminki Kari, Ji Jianguang, Sundquist Jan, Shu Xiaochen

Abstract excerpt

PURPOSE: Cancer of unknown primary (CUP) is diagnosed at the metastatic stage, and despite extensive diagnostic work-up, the primary tumor often remains unidentified. No data are available on familial clustering of CUP. We hypothesize that familial clustering of CUP with other cancers may be informative of the primary sites. PATIENTS AND METHODS: A total of 35,168 patients with CUP were identified in the Swedish...

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PMID: 21189391
DOI: 10.1200/JCO.2010.31.5614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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