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Article

Cancer of unknown primary (CUP): does cause of death and family history implicate hidden phenotypically changed primaries?

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2012

Hemminki K, Bevier M, Sundquist J, Hemminki A

Abstract excerpt

BACKGROUND: Cancer of unknown primary (CUP) is diagnosed at the metastatic stage. We aimed to identify hidden primary cancers in CUP patients by comparison with cancers in family members. We take use of the fact that the cause of death in CUP patients is often coded as the cancer in the organ of fatal metastasis. PATIENTS AND METHODS: Forty-one thousand five hundred and twenty-three CUP patients were identified...

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PMID: 22473595
DOI: 10.1093/annonc/mds063

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