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Article

NOBOX homeobox mutation causes premature ovarian failure.

American journal of human genetics - 1 Sept 2007

Qin Yingying, Choi Youngsok, Zhao Han, Simpson Joe Leigh, Chen Zi-Jiang, Rajkovic Aleksandar

Abstract excerpt

NOBOX (newborn ovary homeobox gene) is an oocyte-specific homeobox gene that plays a critical role in early folliculogenesis and represents a candidate gene for nonsyndromic ovarian failure. We investigated whether mutations in the NOBOX gene cause premature ovarian failure (POF). We sequenced th...

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Source

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Identifiers

PMID: 17701902
DOI: 10.1086/519496
PMCID: PMC1950834

Genes

NOBOX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17701902-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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NOBOX homeobox mutation causes premature ovarian failure.PMID 17701902Read ↗

Mutation analysis of NOBOX homeodomain in Chinese women with premature ovarian failure.Semantic proximity Read ↗

Novel NOBOX loss-of-function mutations account for 6.2% of cases in a large primary ovarian insufficiency cohort.Semantic proximity Read ↗

Impaired protein stability and nuclear localization of NOBOX variants associated with premature ovarian insufficiency.Semantic proximity Read ↗

NOBOX is a strong autosomal candidate gene in Tunisian patients with primary ovarian insufficiency.Semantic proximity Read ↗

Compound heterozygous null mutations of NOBOX in sisters with delayed puberty and primary amenorrhea.Semantic proximity Read ↗

Oocyte/zygote/embryo maturation arrest: a clinical study expanding the phenotype of NOBOX variants.Semantic proximity Read ↗

A homozygous NOBOX truncating variant causes defective transcriptional activation and leads to primary ovarian insufficiency.Semantic proximity Read ↗

New NOBOX mutations identified in a large cohort of women with primary ovarian insufficiency decrease KIT-L expression.Semantic proximity Read ↗

NOBOX gene variants in premature ovarian insufficiency: ethnicity-dependent insightsSemantic proximity Read ↗

Next-generation sequencing of 500 POI patients identified novel responsible monogenic and oligogenic variants.Semantic proximity Read ↗

New candidate gene POU5F1 associated with premature ovarian failure in Chinese patients.Semantic proximity Read ↗

A Novel Functional Role for the Oocyte-Specific Transcription Factor Newborn Ovary Homeobox (NOBOX) during Early Embryonic Development in CattleSemantic proximity Read ↗

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