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Article

NOBOX homeobox mutation causes premature ovarian failure.

American journal of human genetics - 1 Sept 2007

Qin Yingying, Choi Youngsok, Zhao Han, Simpson Joe Leigh, Chen Zi-Jiang, Rajkovic Aleksandar

Abstract excerpt

NOBOX (newborn ovary homeobox gene) is an oocyte-specific homeobox gene that plays a critical role in early folliculogenesis and represents a candidate gene for nonsyndromic ovarian failure. We investigated whether mutations in the NOBOX gene cause premature ovarian failure (POF). We sequenced the NOBOX gene in 96 white women with POF and discovered seven known single-nucleotide polymorphisms and four novel...

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Source

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Identifiers

PMID: 17701902
DOI: 10.1086/519496
PMCID: PMC1950834

Genes

NOBOX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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NOBOX homeobox mutation causes premature ovarian failure.PMID 17701902Read ↗

Mutation analysis of NOBOX homeodomain in Chinese women with premature ovarian failure.Semantic proximity Read ↗

Novel NOBOX loss-of-function mutations account for 6.2% of cases in a large primary ovarian insufficiency cohort.Semantic proximity Read ↗

Impaired protein stability and nuclear localization of NOBOX variants associated with premature ovarian insufficiency.Semantic proximity Read ↗

NOBOX is a strong autosomal candidate gene in Tunisian patients with primary ovarian insufficiency.Semantic proximity Read ↗

Compound heterozygous null mutations of NOBOX in sisters with delayed puberty and primary amenorrhea.Semantic proximity Read ↗

Oocyte/zygote/embryo maturation arrest: a clinical study expanding the phenotype of NOBOX variants.Semantic proximity Read ↗

A homozygous NOBOX truncating variant causes defective transcriptional activation and leads to primary ovarian insufficiency.Semantic proximity Read ↗

New NOBOX mutations identified in a large cohort of women with primary ovarian insufficiency decrease KIT-L expression.Semantic proximity Read ↗

NOBOX gene variants in premature ovarian insufficiency: ethnicity-dependent insightsSemantic proximity Read ↗

Next-generation sequencing of 500 POI patients identified novel responsible monogenic and oligogenic variants.Semantic proximity Read ↗

New candidate gene POU5F1 associated with premature ovarian failure in Chinese patients.Semantic proximity Read ↗

A Novel Functional Role for the Oocyte-Specific Transcription Factor Newborn Ovary Homeobox (NOBOX) during Early Embryonic Development in CattleSemantic proximity Read ↗

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