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Article

HMGB1, S100 proteins and other RAGE ligands in cancer - markers, mediators and putative therapeutic targets.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia - 1 Mar 2016

Tesarova Petra, Kalousova Marta, Zima Tomas, Tesar Vladimir

Abstract excerpt

BACKGROUND AND AIMS: Activation of RAGE due to its increased expression in cancer cells or its stimulation by multiple ligands (AGEs, HMGB1, S100 proteins, etc.) may contribute to the proliferation, invasiveness of tumor cells and formation of distant metastases and also to the resistance of cancer to treatment. RAGE ligands could thus become both useful markers of disease severity and its outcome and, a...

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Source

Identifiers

PMID: 26847418
DOI: 10.5507/bp.2016.003

Genes

HMGB1

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