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Article

Lung carcinogenesis by tobacco smoke.

International journal of cancer - 15 Dec 2012

Hecht Stephen S

Abstract excerpt

Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts, leading to miscoding and mutations in critical growth control genes, applies to this mixture but some aspects are difficult to establish because of the complexity of the exposure. This article discusses certain features of this mechanism...

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Identifiers

PMID: 22945513
DOI: 10.1002/ijc.27816
PMCID: PMC3479369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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