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Article

Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination.

Journal of immunology research - 1 Jan 2015

Vormehr Mathias, Schrörs Barbara, Boegel Sebastian, Löwer Martin, Türeci Özlem, Sahin Ugur

Abstract excerpt

Advances in nucleic acid sequencing technologies have revolutionized the field of genomics, allowing the efficient targeting of mutated neoantigens for personalized cancer vaccination. Due to their absence during negative selection of T cells and their lack of expression in healthy tissue, tumor mutations are considered as optimal targets for cancer immunotherapy. Preclinical and early clinical data suggest that...

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Identifiers

PMID: 26844233
DOI: 10.1155/2015/595363
PMCID: PMC4710911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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