Article
Translation of genomics-guided RNA-based personalised cancer vaccines: towards the bedside.
British journal of cancer - 14 Oct 2014
Boisguérin V, Castle J C, Loewer M, Diekmann J, Mueller F, Britten C M, Kreiter S, Türeci Ö, Sahin U
Abstract excerpt
Cancer is a disease caused by DNA mutations. Cancer therapies targeting defined functional mutations have shown clinical benefit. However, as 95% of the mutations in a tumour are unique to that single patient and only a small number of mutations are shared between patients, the addressed medical need is modest. A rapidly determined patient-specific tumour mutation pattern combined with a flexible...
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