Article
Prion protein heterogeneity in sporadic but not variant Creutzfeldt-Jakob disease: UK cases 1991-2002.
Annals of neurology - 1 Jun 2004
Head Mark W, Bunn Tristan J R, Bishop Matthew T, McLoughlin Victoria, Lowrie Suzanne, McKimmie Clive S, Williams Michelle C, McCardle Linda, MacKenzie Jan, Knight Richard, Will Robert G, Ironside James W
Abstract excerpt
Human prion diseases can occur as an idiopathic disorder (sporadic Creutzfeldt-Jakob disease) or can be acquired, as is the case for variant Creutzfeldt-Jakob disease. These disorders are characterized by the accumulation of a protease-resistant form of the host-encoded prion protein termed PrP(Sc) in the brains of affected individuals. PrP(Sc) has been proposed to be the principal, if not sole, component of the...
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