A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.

doi:10.1126/science.1213256

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Article

A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.

Science (New York, N.Y.) - 25 Nov 2011

Pejchal Robert, Doores Katie J, Walker Laura M, Khayat Reza, Huang Po-Ssu, Wang Sheng-Kai, Stanfield Robyn L, Julien Jean-Philippe, Ramos Alejandra, Crispin Max, Depetris Rafael, Katpally Umesh, Marozsan Andre, Cupo Albert, Maloveste Sebastien, Liu Yan, McBride Ryan, Ito Yukishige, Sanders Rogier W, Ogohara Cassandra, Paulson James C, Feizi Ten, Scanlan Christopher N, Wong Chi-Huey, Moore John P, Olson William C, Ward Andrew B, Poignard Pascal, Schief William R, Burton Dennis R, Wilson Ian A

Abstract excerpt

The HIV envelope (Env) protein gp120 is protected from antibody recognition by a dense glycan shield. However, several of the recently identified PGT broadly neutralizing antibodies appear to interact directly with the HIV glycan coat. Crystal structures of antigen-binding fragments (Fabs) PGT 127 and 128 with Man(9) at 1.65 and 1.29 angstrom resolution, respectively, and glycan binding data delineate a specific...

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Identifiers

PMID: 21998254
DOI: 10.1126/science.1213256
PMCID: PMC3280215

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