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Article

Single substitutions to closely related amino acids contribute to the functional diversification of an insect-inducible, positively selected plant cystatin.

The FEBS journal - 1 Apr 2016

Rasoolizadeh Asieh, Goulet Marie-Claire, Sainsbury Frank, Cloutier Conrad, Michaud Dominique

Abstract excerpt

A causal link has been reported between positively selected amino acids in plant cystatins and the inhibitory range of these proteins against insect digestive cysteine (Cys) proteases. Here we assessed the impact of single substitutions to closely related amino acids on the contribution of positive selection to cystatin diversification. Cystatin sequence alignments, while confirming hypervariability, indicated a...

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PMID: 26833679
DOI: 10.1111/febs.13671

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