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Article

Discrimination of differentially inhibited cysteine proteases by activity-based profiling using cystatin variants with tailored specificities.

Journal of proteome research - 7 Dec 2012

Sainsbury Frank, Rhéaume Ann-Julie, Goulet Marie-Claire, Vorster Juan, Michaud Dominique

Abstract excerpt

Recent research has shown the possibility of tailoring the inhibitory specificity of plant cystatins toward cysteine (Cys) proteases by single mutations at positively selected amino acid sites. Here we devised a cystatin activity-based profiling approach to assess the impact of such mutations at the proteome scale using single variants of tomato cystatin SlCYS8 and digestive Cys proteases of the herbivorous...

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PMID: 23082957
DOI: 10.1021/pr300699n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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