Article
Combined local and systemic immunization is essential for durable T-cell mediated heterosubtypic immunity against influenza A virus.
Scientific reports - 1 Feb 2016
Uddback Ida E M, Pedersen Line M I, Pedersen Sara R, Steffensen Maria A, Holst Peter J, Thomsen Allan R, Christensen Jan P
Abstract excerpt
The threat from unpredictable influenza virus pandemics necessitates the development of a new type of influenza vaccine. Since the internal proteins are highly conserved, induction of T cells targeting these antigens may provide the solution. Indeed, adenoviral (Ad) vectors expressing flu nucleoprotein have previously been found to induce short-term protection in mice. In this study we confirm that systemic...
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