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Article

The Long Noncoding RNA SPRIGHTLY Regulates Cell Proliferation in Primary Human Melanocytes.

The Journal of investigative dermatology - 1 Apr 2016

Zhao Wei, Mazar Joseph, Lee Bongyong, Sawada Junko, Li Jian-Liang, Shelley John, Govindarajan Subramaniam, Towler Dwight, Mattick John S, Komatsu Masanobu, Dinger Marcel E, Perera Ranjan J

Abstract excerpt

The long noncoding RNA SPRIGHTLY (formerly SPRY4-IT1), which lies within the intronic region of the SPRY4 gene, is up-regulated in human melanoma cells compared to melanocytes. SPRIGHTLY regulates a number of cancer hallmarks, including proliferation, motility, and apoptosis. To better understand its oncogenic role, SPRIGHTLY was stably transfected into human melanocytes, which resulted in increased cellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26829028
DOI: 10.1016/j.jid.2016.01.018
PMCID: PMC4857189

Genes

SPRY4

Provenance

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