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Article

A Common Variant of PROK1 (V67I) Acts as a Genetic Modifier in Early Human Pregnancy through Down-Regulation of Gene Expression.

International journal of molecular sciences - 27 Jan 2016

Su Mei-Tsz, Huang Jyun-Yuan, Tsai Hui-Ling, Chen Yi-Chi, Kuo Pao-Lin

Abstract excerpt

PROK1-V67I has been shown to play a role as a modifier gene in the PROK1-PROKR system of human early pregnancy. To explore the related modifier mechanism of PROK1-V67I, we carried out a comparison study at the gene expression level and the cell function alternation of V67I, and its wild-type (WT), in transiently-transfected cells. We, respectively, performed quantitative RT-PCR and ELISA assays to evaluate the...

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Identifiers

PMID: 26828479
DOI: 10.3390/ijms17020162
PMCID: PMC4783896

Genes

PROK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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