Evidence of the Importance of the First Intracellular Loop of Prokineticin Receptor 2 in Receptor Function

Abstract excerpt

Prokineticin receptors (PROKR) are G protein-coupled receptors (GPCR) that regulate diverse biological processes, including olfactory bulb neurogenesis and GnRH neuronal migration. Mutations in PROKR2 have been described in patients with varying degrees of GnRH deficiency and are located in diverse functional domains of the receptor. Our goal was to determine whether variants in the first intracellular loop...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hypothalamic control of reproductive hormones
• Share to Neuropeptides and Animal Physiology
• Share to Receptor Mechanisms and Signaling