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Article

VIP and PACAP analogs regulate therapeutic targets in high-risk neuroblastoma cells.

Peptides - 1 Apr 2016

de Boisvilliers Madryssa, Perrin Florian, Hebache Salima, Balandre Annie-Claire, Bensalma Souheyla, Garnier Agnès, Vaudry David, Fournier Alain, Festy Franck, Muller Jean-Marc, Chadéneau Corinne

Abstract excerpt

Neuroblastoma (NB) is a pediatric cancer. New therapies for high-risk NB aim to induce cell differentiation and to inhibit MYCN and ALK signaling in NB. The vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptide (PACAP) are 2 related neuropeptides sharing common receptors. The level of VIP increases with NB differentiation. Here, the effects of VIP and PACAP analogs...

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Share to Anaplastic Lymphoma Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pituitary Adenylate Cyclase-Activating Polypeptide

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Source

Identifiers

PMID: 26826611
DOI: 10.1016/j.peptides.2016.01.014

Genes

VIP
MYCN
ALK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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VIP and PACAP analogs regulate therapeutic targets in high-risk neuroblastoma cells.PMID 26826611Read ↗

VIP and pituitary adenylate cyclase activating polypeptide (PACAP) have an antiproliferative effect on the T98G human glioblastoma cell line through interaction with VIP2 receptorSemantic proximity Read ↗

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MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathwaySemantic proximity Read ↗

CAMKV Kinase Signaling Is a Novel Therapeutic Avenue with Prognostic Relevance in NeuroblastomaSemantic proximity Read ↗

Phosphorylation of MYCN and MAX by PAK family kinases is a novel tumor-suppressor mechanism in neuroblastoma with potential therapeutic implicationsSemantic proximity Read ↗

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