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Article

Targeting gastrin-releasing peptide suppresses neuroblastoma progression via upregulation of PTEN signaling.

PloS one - 1 Jan 2013

Paul Pritha, Qiao Jingbo, Kim Kwang Woon, Romain Carmelle, Lee Sora, Volny Natasha, Mobley Bret, Correa Hernan, Chung Dai H

Abstract excerpt

We have previously demonstrated the role of gastrin-releasing peptide (GRP) as an autocrine growth factor for neuroblastoma. Here, we report that GRP silencing regulates cell signaling involved in the invasion-metastasis cascade. Using a doxycycline inducible system, we demonstrate that GRP silencing decreased anchorage-independent growth, inhibited migration and neuroblastoma cell-mediated angiogenesis in vitro,...

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Source

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Identifiers

PMID: 24039782
DOI: 10.1371/journal.pone.0072570
PMCID: PMC3767701

Genes

GRP
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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