Article
Association of BRAF V600E mutations with vasoactive intestinal peptide syndrome in MYCN-amplified neuroblastoma.
Pediatric blood & cancer - 1 Oct 2021
Shahid Sanam, Kushner Brian H, Modak Shakeel, Basu Ellen M, Rubin Elyssa M, Gundem Gunes, Papaemmanuil Elli, Roberts Stephen S
Abstract excerpt
Very rarely, vasoactive intestinal peptide-related diarrhea (VIP-D) is observed in patients with high-risk neuroblastoma (HR-NB) where the associated fluid and electrolyte abnormalities can pose a major clinical challenge for administering the required aggressive multimodality treatment. Two patients with HR-NB developed VIP-D during induction and were found to have a somatic BRAF V600E mutation. Serum VIP levels...
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