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Article

Differential regulation and synthetic lethality of exclusive RB1 and CDKN2A mutations in lung cancer.

International journal of oncology - 1 Jan 2016

Kim Nayoung, Song Mee, Kim Somin, Seo Yujeong, Kim Yonghwan, Yoon Sukjoon

Abstract excerpt

Genetic alterations in lung cancer are distinctly represented in non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC). Mutation of the RB1 and CDKN2A genes, which are tightly associated with cell cycle regulation, is exclusive to SCLC and NSCLC cells, respectively. Through the systematic analysis of transcriptome and proteome datasets for 318 cancer cell lines, we characterized differential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26647789
DOI: 10.3892/ijo.2015.3262
PMCID: PMC6903902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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